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I've taken I-75 to Rt 6, and it's not a bad drive. Roughly 4 hours, and Rt 6 is a pretty good road the whole way.
I am in Columbus and drive several different routes but it is mostly two lane roads and looks to only save 20 minutes or so off the 75 and 6 route. I would stick to 75-6 especially if you do not have reliable GPS and there are frequent construction detours and small town speed traps on the back roads.