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I agree with Tabto that Waze is a great app. But, having been pulled onto Highway 2 a couple times over the last few years while 80/90 was under construction, I've concluded that I will always drive 80/90. Psychologically it has always felt faster to be on the highway than it does being stuck behind a car going 45 on a two lane road (which you are fated to do on Highway 2) even during Norther Ohio's chronic road construction. Therefore, I suggest taking 75 south to 475 east to 80/90 east.
B138 -
If you take 475 you are going to end up doing a loop around the whole city of Toledo. If you take 75 South from Michigan, you want to catch 280 to the turnpike.
I live in Euclid, first eastern suburb of Cleveland. I go to Michigan for automotive events. Woodward dream cruise, Michigan 'meet & greet' for Camaros and Firebirds, Camaro 'Superfest'. Always stop into Cedar Point on the way back. It's always split between Rt.2 all the way to Sandusky OR the turnpike to Rt.4 and up to Sandusky. One is slower and less miles and the other faster and more miles. Never had a difference in time to Cedar Point. BUT everything is dependent on traffic and conditions.
I always use Rt.23 in Michigan and avoid Michigans' interstates.